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Interview Questions and Answers

OHDSI ATLAS is a web-based platform used to perform observational research, cohort definitions, data visualization, and analysis using the OMOP Common Data Model.

The OMOP CDM is a standardized data structure that harmonizes healthcare data from different sources, enabling consistent research across institutions.

ATLAS provides a graphical interface for cohort creation, vocabulary browsing, concept set building, and running evidence-generating studies.

A Concept Set is a reusable collection of standardized medical concepts (conditions, drugs, procedures) used to define cohorts and analyses.

A Cohort Definition specifies a set of criteria to identify patients from observational health data using events and time restrictions.

The Vocabulary Browser allows users to search and explore standardized medical terminologies such as SNOMED, RxNorm, ICD, CPT, and LOINC.

ATLAS works with OMOP CDM-compatible databases like PostgreSQL, SQL Server, Oracle, and Redshift.

Achilles is a tool used for automated quality assessment, data summarization, and overview reporting of OMOP CDM datasets.

WebAPI connects ATLAS to backend databases, enabling cohort execution, vocabulary queries, and result retrieval.

Cohort Pathways show the order in which patients experience clinical events, helping analyze treatment sequences or disease progression.

Characterization Reports summarize attributes of cohorts such as demographics, medication use, comorbidities, and event frequencies.

It estimates causal relationships by comparing outcomes between exposed and unexposed patient cohorts using observational data.

These models use machine learning to predict patient outcomes, such as risk of hospitalization or disease progression.

ATLAS ensures that cohort definitions, concept sets, and analyses are stored in standardized formats for re-use and cross-database study replication.

Yes, ATLAS can be deployed on local servers using WebAPI with security configurations and CDM-compliant databases.

The ETL (Extract, Transform, Load) process converts source healthcare data into the OMOP CDM while mapping vocabulary codes to standardized terminologies.

ATLAS supports authentication, authorization roles, and customizable user access policies when configured with security frameworks.

R and SQL are widely used for running analyses, generating reports, and interacting with study packages.

OHDSI uses a federated research model where institutions run studies locally and only share summary-level results, not patient-level data.

Knowledge of medical vocabularies, observational study design, SQL, OMOP CDM structure, and basic epidemiology.